What is New in the 2016 Revision to WHO Classification of Myelodysplastic Syndromes?
نویسنده
چکیده
The morphologic dysplasia manifested in any lineage(s) frequently does not correlate with the specific cytopenia(s) in individual MDS cases. For this reason, WHO revision for adult MDS classification in 2016 removes terms such as “refractory anemia” and “refractory cytopenia” and replaces them with “myelodysplastic syndrome” followed by the appropriate modifiers: single vs multilineage dysplasia, ring sideroblasts, excess blasts, or the del(5q) cytogenetic abnormality. In addition, the diagnostic criteria for MDS-RS is based on the detection of SF3B1 mutations, the cytogenetic criteria for MDS with isolated del (5q) is modified, most cases of the erythroid/myeloid type of acute erythroleukemia are reclassified, and the familial link in some cases of MDS are recognized. Abbreviations: MDS: myelodysplastic syndromes; HSC: hematopoietic stem cell; AML: acute myeloid leukemia; t-MDS: therapy-related MDS; ICUS: Idiopathic cytopenia(s) of undetermined significance; CHIP: clonal hematopoiesis of indeterminate potential; IPSS: International prognostic scoring system; WPSS: WHO prognostic scoring system; MDAS: MD Anderson score; LR-MDAS: MDAS for low-risk patients; AXSL1: Additional sex-comb-like transcriptional regulator-1; MDS-U: MDS, unclassifiable; MDS-RS: MDS with ring sideroblasts; FISH; fluorescent hybridization in situ; aCGH: array Comparative Genomic Hybridization.
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